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Cell-destructive activity in the serum of a tumor patient after infusion of alkyl lysophospholipid

Andreesen, Reinhard ; Munder, P. G.


Sera collected from 1 tumor patient after a 12-hour infusion of 30-50 mg alkyl lysophospholipids (ALP)/kg induced a progressive destruction of human leukemia cells (HL60) in vitro. This cytotoxic serum activity correlated with the dose of ALP administered and was inhibited by the addition of a metabolizable lysophospholipid analogue. Human bone marrow cells and concanavalin A-stimulated ...


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