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Studies on various parameters influencing leukemic cell destruction by alkyl-lysophospholipids

Andreesen, Reinhard ; Modolell, M. ; Oepke, G. H. ; Common, H. ; Löhr, G. W. ; Munder, P. G.


Critical parameters of alkyl-lysophospholipid (ALP) induced destruction of freshly isolated human leukemic cells have been evaluated. The destructive activity of ALP is shown to be competitively inhibited by metabolizable lysophospholipids added to the cultures. It has also been found that destruction depends on the amount of serum present. Temperature and Ph strongly influence the cytotoxic ...


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