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Expression of transferrin receptors and intracellular ferritin during terminal differentiation of human monocytes

Andreesen, Reinhard ; Osterholz, J. ; Bodemann, H. ; Bross, K. J. ; Costabel, U. ; Löhr, G. W.



Abstract

Human blood monocytes when cultured on hydrophobic Teflon membranes differentiate into mature macrophages. The expression of transferrin receptors was monitored by monoclonal antibody (OKT9) binding as detected by immunoperoxidase staining. Whereas monocytes were negative, an increasing percentage of macrophages, starting from day 2 in culture, labelled with the antitransferrin receptor antibody ...

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