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Differential effects of ether lipids on the activity and secretion of interleukin-1 and interleukin-2

Andreesen, Reinhard ; Giese, V.



Abstract

Alkyl lysophospholipids (ALP) are synthetic analogues of lysophosphatidylcholine and represent a new generation of antitumor drugs currently being tested in phase-I trials in patients with cancer. The present study reports the differential modulation of human immunocompetent cells in vitro by ALP. Serum-bound ALP effectively blocked the response of growth factor-dependent cells to interleukin-2 ...

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