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Human macrophage maturation and heterogeneity: restricted expression of late differentiation antigens in situ

Andreesen, Reinhard ; Gadd, S. ; Costabel, U. ; Leser, H. G. ; Speth, V. ; Cesnik, B. ; Atkins, R. C.



Abstract

Terminal maturation of human macrophages is an important step for creation of cell diversity amongst site-specific subpopulations and their functional competence in situ. As monocytes undergo differentiation in vitro, they start to express lineage-restricted antigens specific for differentiation stages beyond the blood monocyte level as detected by monoclonal antibodies of the MAX series. We have ...

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