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Defective monocyte to macrophage maturation in human immunodeficiency virus infection

Andreesen, Reinhard ; Brugger, W. ; Kunze, R. ; Stille, W. ; von Briesen, H.


To look for possible defects in cells of the monocyte/macrophage system, blood monocytes from patients infected with human immunodeficiency virus (HIV) were cultured on hydrophobic Teflon for 7 days and their ability to differentiate into mature macrophages in the presence of serum was followed. The following parameters were studied as indicative of successful terminal maturation: (1) the ...


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