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The polysulphated polyxylan Hoe/Bay-946 inhibits HIV replication on human monocytes/macrophages

von Briesen, H. ; Meichsner, C. ; Andreesen, Reinhard ; Esser, R. ; Schrinner, E. ; Rübsamen-Waigmann, H.



Abstract

Due to the important role of monocytes/macrophages in the pathogenesis of AIDS, potential drugs with anti-HIV activity in lymphocytes must also be effective in monocytes/macrophages. For testing the efficacy of antiviral substances, monocytes/macrophages from peripheral blood were infected, respectively, with highly replicating HIV1 and HIV2 strains, thereby providing an extremely sensitive ...

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