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Adoptive transfer of tumor cytotoxic macrophages generated in vitro from circulating blood monocytes: a new approach to cancer immunotherapy

Andreesen, Reinhard ; Scheibenbogen, C. ; Brugger, W. ; Krause, S. ; Meerpohl, H. G. ; Leser, H. G. ; Engler, H. ; Löhr, G. W.



Abstract

Cells of the macrophage lineage are considered to be of special importance in the defense of the host against tumor development and spread. Immunotherapeutic strategies to stimulate macrophage (MAC) tumor cytotoxicity make use of activating compounds such as gamma-interferon which are given systemically. However, there are several lines of evidence that in malignant disease the generation of ...

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