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Mitoxantrone/high-dose Ara-C and recombinant human GM-CSF in the treatment of refractory non-Hodgkin's lymphoma. A pilot study

Ho, A. D. ; Del Valle, F. ; Engelhard, M. ; Hiddemann, W. ; Rückle, H. ; Schlimok, G. ; Haas, R. ; Thiel, E. ; Andreesen, Reinhard ; Fiedler, W.



Abstract

Previous study has shown that the combination of mitoxantrone (Novantrone, NO) and Ara-C (AC) (NOAC) was active in refractory non-Hodgkin's lymphoma (NHL) but myelosuppression was dose-limiting. In a pilot study, we investigated the effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) after NOAC chemotherapy in patients with refractory NHL. NO was applied at a ...

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