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Elevation of serum interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis

Leser, H. G. ; Gross, V. ; Scheibenbogen, C. ; Heinisch, A. ; Salm, R. ; Lausen, M. ; Rückauer, K. ; Andreesen, Reinhard ; Farthmann, E. H. ; Schölmerich, J.



Abstract

Experimental studies have shown that interleukin-6 induces all major acute-phase proteins in the liver, including C-reactive protein. In 50 patients with acute pancreatitis, the serum concentrations of interleukin-6 and C-reactive protein were determined daily during the first week of hospitalization. Patients were divided into three groups according to clinical criteria: mild pancreatitis (less ...

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