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Macrophage colony-stimulating factor is required for human monocyte survival and acts as a cofactor for their terminal differentiation to macrophages in vitro

URN to cite this document:
urn:nbn:de:bvb:355-epub-142690
Brugger, W. ; Kreutz, Marina ; Andreesen, Reinhard
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Date of publication of this fulltext: 14 Apr 2010 05:24


Abstract

Functional competence as well as phenotype heterogeneity of macrophages depend on the completion of their maturation pathway. Differentiation of committed myeloid progenitor cells is induced by colony-stimulating factors (CSF), but no consistent data exist on which factor(s) induce the terminal maturation from the circulating blood monocyte to the mature macrophage. In vitro, monocyte to ...

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