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Adoptive immunotherapy of solid tumors with activated macrophages: experimental and clinical results

Bartholeyns, J. ; Lopez, M. ; Andreesen, Reinhard


Adoptive immunotherapy in cancer has been essentially restricted to the use of lymphoid effector cells (NK, TIL, LAK) stimulated with IL-2. Differentiated macrophages represent another key effector population even more important for the immune control of cancer. We have shown that activated murine macrophages reduced primary tumors and experimental metastases. Human macrophages differentiated ...


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