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Generation of cytokines in human visceral leishmaniasis: dissociation of endogenous TNF-alpha and IL-1 beta production

Zwingenberger, K., Harms, G., Pedrosa, C., Pessoa, M. C., Sandkamp, B., Scheibenbogen, C. and Andreesen, Reinhard (1991) Generation of cytokines in human visceral leishmaniasis: dissociation of endogenous TNF-alpha and IL-1 beta production. Immunobiology 183 (1-2), pp. 125-32.

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Abstract

The role of TNF-alpha in visceral leishmaniasis is ambivalent, the eventual outcome of this infection, cure or generalization, being determined by the relative amounts of cytokines produced in vivo. Since release, by monocytes/macrophages, of TNF-alpha and interleukins 1 beta (IL-1 beta) and IL-6 is important in both the induction and effector phases of the immune responses, these mediators were ...

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Item type:Article
Date:1991
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
1937561PubMed ID
Classification:
NotationType
AdolescentMESH
AdultMESH
AnimalsMESH
Biopterin/metabolismMESH
Brazil/epidemiologyMESH
ChildMESH
Child, PreschoolMESH
Cytokines/metabolismMESH
FemaleMESH
HumansMESH
Interleukin-1/metabolismMESH
Interleukin-6/metabolismMESH
Leishmania donovani/immunologyMESH
Leishmaniasis, Visceral/immunologyMESH
Macrophages/metabolismMESH
MaleMESH
Mitogens/metabolismMESH
Monocytes/metabolismMESH
NeopterinMESH
Tumor Necrosis Factor-alpha/metabolismMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:14275
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