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Interferon-gamma-induced expression of tissue factor activity during human monocyte to macrophage maturation

Scheibenbogen, C. ; Moser, H. ; Krause, S. ; Andreesen, Reinhard



Abstract

The expression of tissue factor (TF) during differentiation of human monocytes (MO) to macrophages (MAC) in vitro is investigated in this study. In MO, TF activity can be induced by the addition of lipopolysaccharides (LPS) as detected by Northern blot analysis and measured functionally as procoagulant activity (PCA), while IFN gamma alone has only marginal stimulatory activity. During in vitro ...

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