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1,25-dihydroxyvitamin D3 production and vitamin D3 receptor expression are developmentally regulated during differentiation of human monocytes into macrophages

URN to cite this document:
Kreutz, Marina ; Andreesen, Reinhard ; Krause, S. W. ; Szabo, A. ; Ritz, E. ; Reichel, H.
Date of publication of this fulltext: 14 Apr 2010 05:12


It has been well established that human mononuclear phagocytes have the capacity to produce 1,25-dihydroxy-vitamin D3 [1,25(OH)3D3] and express the vitamin D receptor (VDR). However, 1 alpha-hydroxylase activity and VDR receptor expression during differentiation of monocytes (MO) into mature macrophages (MAC) have not been previously examined. The in vitro maturation of blood MO can serve as a ...


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