URN zum Zitieren dieses Dokuments: urn:nbn:de:bvb:355-epub-142861
Schlesier, M., Krause, S., Dräger, R., Wolff-Vorbeck, G., Kreutz, Marina, Andreesen, Reinhard und Peter, H. H.
(1994)
Monocyte differentiation and accessory function: different effects on the proliferative responses of an autoreactive T cell clone as compared to alloreactive or antigen-specific T cell lines and primary mixed lymphocyte cultures.
Immunobiology 190 (1-2), S. 164-174.
Zum PubMed-Eintrag dieses Artikels
Zusammenfassung
An autoreactive T cell clone derived from a patient with reactive arthritis, two alloreactive T cell lines, two antigen-specific T cell lines and allogeneic resting T cells were analyzed for their responses to monocytes and macrophages derived from monocytes by in vitro differentiation. The autoreactive T cell clone strongly proliferated in response to fresh monocytes and to macrophages derived ...
Zusammenfassung
An autoreactive T cell clone derived from a patient with reactive arthritis, two alloreactive T cell lines, two antigen-specific T cell lines and allogeneic resting T cells were analyzed for their responses to monocytes and macrophages derived from monocytes by in vitro differentiation. The autoreactive T cell clone strongly proliferated in response to fresh monocytes and to macrophages derived from a 7 day culture, but only poorly to monocytes cultured for 2 days. In contrast, alloreactive and antigen-specific T cell lines proliferated to all stimulatory cells equally well. Finally, primary mixed lymphocyte reactions could be stimulated by both fresh and 2-day cultured monocytes, but not by in vitro derived macrophages. The impaired response of the autoreactive T cell clone to 2-day cultured monocytes could not be attributed to reduced expression of several well-defined surface molecules nor to induction of nonresponsiveness. Neither allogeneic monocytes nor cytokines (IL-1, IL-2, IL-4, IL-6) could correct the defective response of the autoreactive T cell clone. However, preculture of monocytes in the presence of interferon-gamma, IL-1, IL-4 or IL-6 retained their stimulatory capacity. Our interpretation of the selectively impaired response of the autoreactive T cell clone is that it most likely recognizes a differentiation-dependent monocyte/macrophage-specific peptide.
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| Dokumentenart: | Artikel |
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| Datum: | 1994 |
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| Institutionen: | Medizin > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
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| Identifikationsnummer: | |
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| Klassifikation: | | Notation | Art |
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| Antigen-Presenting Cells/immunology | MESH | | Antigens, Surface/biosynthesis | MESH | | Autoantigens/immunology | MESH | | Cell Differentiation/physiology | MESH | | Cell Division/immunology | MESH | | Cell Line | MESH | | Epitopes/immunology | MESH | | Humans | MESH | | Isoantigens/immunology | MESH | | Lymphocyte Activation/immunology | MESH | | Lymphocyte Culture Test, Mixed | MESH | | Monocytes/immunology | MESH | | T-Lymphocyte Subsets/immunology | MESH |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Eingebracht am: | 14 Apr 2010 05:10 |
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| Zuletzt geändert: | 08 Mrz 2017 08:25 |
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| Dokumenten-ID: | 14286 |
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