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Chemomodulation of drugs involved in multidrug resistance in chronic lymphatic leukemia of the B-cell type

Reichle, A. ; Diddens, H. ; Altmayr, F. ; Rastetter, J. ; Andreesen, Reinhard



Abstract

Reduced drug accumulation may be one reason for intrinsic drug resistance in chronic lymphatic leukemia of the B-cell type (B-CLL). Immunophenotyped leukemic human B-cells from 38 cases of B-CLL were characterized for P-glycoprotein (PGP) content. In all, 30 cases of B-CLL were additionally analyzed for further parameters: accumulation of daunorubicin (DNR, n = 20) and rhodamine 123 (Rh123, n = ...

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