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Beta-tubulin and P-glycoprotein: major determinants of vincristine accumulation in B-CLL cells

Reichle, A. ; Diddens, H. ; Altmayr, F. ; Rastetter, J. ; Andreesen, Reinhard



Abstract

Vincristine (VCR) accumulation in chronic lymphatic leukemia of B-cell origin (B-CLL) has recently been shown not to be inversely correlated to P-glycoprotein (PGP) levels. Therefore, we studied, in addition to PGP expression and accumulation of VCR, the cellular beta-tubulin content in quiescent and rhIL-2 activated B-CLL cells. VCR mediates cytotoxicity by binding to tubulin. Constitutive ...

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