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Interferon-alpha does not improve the antineoplastic efficacy of high-dose infusional 5-fluorouracil plus folinic acid in advanced colorectal cancer. First results of a randomized multicenter study by the Association of Medical Oncology of the German Cancer Society (AIO)

Köhne, C. H. ; Wilke, H. ; Hecker, H. ; Schöffski, P. ; Käufer, C. ; Rauschecker, H. ; Andreesen, Reinhard ; Ohl, U. ; Lange, H. J. ; Klaassen, U.


BACKGROUND: High-dose 5-FU given weekly as a 24-h infusion in combination with folinic acid (FA) has been associated with low toxicity and a high response rate. Interferon-alpha (IFN) either alone or in combination with FA has also improved treatment results by modulating 5-FU activity. We therefore initiated a randomized multicenter trial comparing the ability of FA or IFN to modulate infusional ...


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