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Molecular cloning of a novel macrophage maturation-associated transcript encoding a protein with several potential transmembrane domains

Rehli, M. ; Krause, S. W. ; Schwarzfischer, L. ; Kreutz, M. ; Andreesen, Reinhard



Abstract

Differentiation of tissue macrophages from bone marrow progenitor cells via circulating blood monocytes is a complex and multistep process. In order to analyze macrophage maturation on the molecular level we used the method of mRNA differential display to identify novel genes that are preferentially expressed in mature, in vitro differentiated macrophages. A PCR-fragment could be isolated that ...

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