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Differential screening identifies genetic markers of monocyte to macrophage maturation

Krause, S. W. ; Rehli, M. ; Kreutz, M. ; Schwarzfischer, L. ; Paulauskis, J. D. ; Andreesen, Reinhard



Abstract

Maturation of cells of the mononuclear phagocyte lineage from bone marrow precursors to tissue macrophages (MAC) via circulating blood monocytes (MO) is a multistep process only partially understood. Similarly, MAC differentiation can be observed if MO are cultured in vitro. In an attempt to further characterize molecular changes occurring during this process we carried out differential screening ...

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