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The human lysozyme gene undergoes stepwise demethylation during phagocyte maturation

Lübbert, M. ; Henschler, R. ; Kreutz, M. ; Andreesen, Reinhard ; Mertelsmann, R. ; Herrmann, F.


The lysozyme (LZM) gene provides a very useful model for studies of phagocyte maturation, because its protein synthesis is increased during myelopoiesis and thus most abundant in terminally differentiated and activated phagoyctes. LZM gene expression and DNA methylation were examined in various normal and transformed hematopoietic cells. Two shifts toward LZM gene demethylation coincided with ...


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