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Carboxypeptidase M as a marker of macrophage maturation

Krause, S. W. ; Rehli, M. ; Andreesen, Reinhard



Abstract

During terminal maturation of blood monocytes (MO) into macrophages (MAC), a multitude of phenotypic and functional changes occur: cells increase in size and enhance their capacity for phagocytosis and tumor cytotoxicity, but decrease their ability for T-lymphocyte stimulation. The pattern of secreted cytokines is shifted as is the profile of surface antigens. The identity of the MAC ...

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