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Platelets induce monocyte differentiation in serum-free coculture

Ammon, C. ; Kreutz, M. ; Rehli, M. ; Krause, S. W. ; Andreesen, Reinhard


Terminal maturation of blood monocytes (MO) in vitro and in vivo into macrophages (MAC) occurs as a result of interactions with various cell types. To characterize some of the cell-cell connections that may be important for MO differentiation we cocultured human MO with lymphocytes and/or with platelets. We found that intact platelets strongly promoted MO maturation under serum-free conditions as ...


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