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Adoptive immunotherapy of cancer using monocyte-derived macrophages: rationale, current status, and perspectives

Andreesen, Reinhard ; Hennemann, B. ; Krause, S. W.



Abstract

Adoptive transfer of host defense cells may be able to correct an otherwise defective generation of competent immune cells in patients with cancer. Ex vivo-grown cytotoxic macrophages (MAC) able to recognize and destroy tumor cells but not normal cells are effective in murine models of metastasizing tumors. After the development of large-scale technology to generate MAC in vitro from blood ...

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