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Retinoic acid inhibits monocyte to macrophage survival and differentiation

Kreutz, M. ; Fritsche, J. ; Ackermann, U. ; Krause, S. W. ; Andreesen, Reinhard


Vitamin A metabolites are potent differentiation-inducing agents for myelomonocytic cell lines in vitro and are successfully used for the treatment of patients with acute promyelocytic leukemia. However, little is known about the effects of vitamin A on normal hematopoietic cells. Therefore, we investigated the effect of vitamin A on differentiation and activation of human blood monocytes (MO). ...


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