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Comparative analysis of dendritic cells derived from blood monocytes or CD34+ hematopoietic progenitor cells

Meierhoff, G. ; Krause, S. W. ; Andreesen, Reinhard



Abstract

In human tissues different populations of dendritic cells (DC) emerge from hematopoietic progenitor cells (HPC) in the bone marrow, with the intermediate steps of differentiation not being completely understood. In vitro, DC can be directly obtained from HPC or from blood monocytes (MO) cultured in the presence of GM-CSF and additional cytokines. We compared the antigenic profile of DC derived ...

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