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Expression of retinoid receptors during human monocyte differentiation in vitro

Fritscher, J. ; Stonehouse, T. J. ; Katz, D. R. ; Andreesen, Reinhard ; Kreutz, M.



Abstract

1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)VD(3)) and retinoic acid (RA) modulate the activation of monocytes (MO) and their differentiation into macrophages (MAC). As these effects are mostly mediated by heterodimers or homodimers of the specific nuclear receptors for 1,25(OH)(2)VD(3) and RA, we investigated the expression of the retinoic acid receptors (RAR) alpha, beta, and gamma and the ...

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