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Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients

Hantschel, M. ; Pfister, K. ; Jordan, A. ; Scholz, R. ; Andreesen, Reinhard ; Schmitz, G. ; Schmetzer, H. ; Hiddemann, W. ; Multhoff, G.



Abstract

A tumor-selective cell surface localization of heat shock protein 70 (Hsp70), the major heat-inducible member of the Hsp70 group, correlates with an increased sensitivity to lysis mediated by human natural killer (NK) cells and, therefore, might be of clinical relevance. With the exception of mammary carcinomas, an Hsp70 plasma membrane expression was found on freshly isolated human biopsy ...

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