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Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation

Holler, E. ; Roncarolo, M. G. ; Hintermeier-Knabe, R. ; Eissner, G. ; Ertl, B. ; Schulz, U. ; Knabe, H. ; Kolb, H. J. ; Andreesen, Reinhard ; Wilmanns, W.


IL-10 is a potent immunosuppressant which inhibits allo-antigen-specific T cell responses. In addition, IL-10 is a strong endogenous anti-inflammatory cytokine. To investigate the role of IL-10 in the induction of acute GVHD following allogeneic bone marrow transplantation (BMT) we performed a prospective study on spontaneous IL-10 production by peripheral blood mononuclear cells (PBMNC) in 84 ...


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