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Analysis of cellular factors influencing the replication of human immunodeficiency virus type I in human macrophages derived from blood of different healthy donors

Eisert, V. ; Kreutz, M. ; Becker, K. ; Königs, C. ; Alex, U. ; Rübsamen-Waigmann, H. ; Andreesen, Reinhard ; von Briesen, H.



Abstract

We analyzed parameters influencing HIV-1 infectibility of cells of the monocyte/macrophage lineage (MO/MAC) isolated from different healthy donors. The proportion of in vitro-infected cells and replication kinetics in different donor MAC ranged from 0.03 to 99% p24 antigen-positive MAC and from undetectable RT activity up to 5 x 10(6) cpm/ml/90 min, respectively. As a quantitative measurement for ...

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