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Activation of lymphocytes inhibits human monocyte to macrophage differentiation

Krause, S. W. ; Zaiss, M. ; Kreutz, M. ; Andreesen, Reinhard



Abstract

Tissue macrophages (MAC) differentiate from circulating blood monocytes (MO) during a maturation step that is of crucial importance for their functional competence. In vitro a similar process of maturation can be observed, if MO are cultured in the presence of serum. In the work presented here, we show that activated lymphocytes can interfere with MAC differentiation. Resting lymphocytes have ...

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