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Is first-line single-agent mitoxantrone in the treatment of high-risk metastatic breast cancer patients as effective as combination chemotherapy? No difference in survival but higher quality of life were found in a multicenter randomized trial

Heidemann, E., Stoeger, H., Souchon, R., Hirschmann, W.-D., Bodenstein, H., Oberhoff, C., Fischer, J. T., Schulze, M., Clemens, M., Andreesen, Reinhard, Mahlke, M., König, M., Scharl, A., Fehnle, K. and Kaufmann, M. (2002) Is first-line single-agent mitoxantrone in the treatment of high-risk metastatic breast cancer patients as effective as combination chemotherapy? No difference in survival but higher quality of life were found in a multicenter randomized trial. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 13 (11), pp. 1717-29.

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Abstract

BACKGROUND: To determine whether patients with high-risk metastatic breast cancer draw benefit from combination chemotherapy as first-line treatment. PATIENTS AND METHODS: A total of 260 women with measurable metastatic breast cancer fulfilling high-risk criteria, previously untreated with chemotherapy for their metastatic disease, were randomized to receive either mitoxantrone 12 mg/m(2) or the ...

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Item type:Article
Date:2002
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
12419743PubMed ID
Classification:
NotationType
AdultMESH
AgedMESH
Antineoplastic Combined Chemotherapy Protocols/therapeutic useMESH
Biopsy, NeedleMESH
Bone Neoplasms/secondaryMESH
Breast Neoplasms/pathologyMESH
Cyclophosphamide/administration & dosageMESH
Disease-Free SurvivalMESH
Epirubicin/administration & dosageMESH
FemaleMESH
Fluorouracil/administration & dosageMESH
GermanyMESH
HumansMESH
Liver Neoplasms/secondaryMESH
Logistic ModelsMESH
Lung Neoplasms/secondaryMESH
Middle AgedMESH
Mitoxantrone/administration & dosageMESH
Neoplasm StagingMESH
ProbabilityMESH
Proportional Hazards ModelsMESH
Quality of LifeMESH
Risk AssessmentMESH
Sensitivity and SpecificityMESH
Statistics, NonparametricMESH
Survival AnalysisMESH
Treatment OutcomeMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:14412
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