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Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation

Fritsche, Jana ; Müller, Alexandra ; Hausmann, Martin ; Rogler, Gerhard ; Andreesen, Reinhard ; Kreutz, Marina


Two members of the ADAM (a disintegrin and metalloprotease)-family, MADDAM and decysin, were described as dendritic cell (DC) maturation markers. We are interested in monocyte differentiation and investigated in particular the expression pattern of both genes during the differentiation of human monocytes into DC and macrophages (MAC). Both genes are weakly expressed in freshly isolated monocytes. ...


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