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Survival and tumor localization of adoptively transferred Melan-A-specific T cells in melanoma patients

Meidenbauer, Norbert ; Marienhagen, Joerg ; Laumer, Monika ; Vogl, Sandra ; Heymann, Jana ; Andreesen, Reinhard ; Mackensen, Andreas


Adoptive T cell therapy has been successfully used for treatment of viral and malignant diseases. However, little is known about the fate and trafficking of transferred Ag-specific T cells. Using the tetramer (TM) technology which allows for detection and quantification of Ag-specific CTL, we assessed the frequency of circulating Melan-A-specific CTL in advanced melanoma patients during adoptive ...


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