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Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation

Rehli, Michael ; Niller, Hans Helmut ; Ammon, Christoph ; Langmann, Sabine ; Schwarzfischer, Lucia ; Andreesen, Reinhard ; Krause, Stefan W.


The protein product of the CHI3L1 gene, human cartilage 39-kDa glycoprotein (HC-gp39), is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyte/macrophage markers, its expression is absent in monocytes and strongly induced during late stages of human macrophage differentiation. To gain insights into the molecular mechanisms ...


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