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Long-term results of first-line sequential high-dose etoposide, ifosfamide, and cisplatin chemotherapy plus autologous stem cell support for patients with advanced metastatic germ cell cancer: an extended phase I/II study of the German Testicular Cancer Study Group

Schmoll, H.-J. ; Kollmannsberger, C. ; Metzner, B. ; Hartmann, J. T. ; Schleucher, N. ; Schöffski, P. ; Schleicher, J. ; Rick, O. ; Beyer, J. ; Hossfeld, D. ; Kanz, L. ; Berdel, W. E. ; Andreesen, Reinhard ; Bokemeyer, C.



Abstract

PURPOSE: Patients with disseminated germ cell cancer and poor prognosis (International Germ Cell Cancer Collaborative Group [IGCCCG] classification) achieve only a 45% to 50% long-term survival by standard chemotherapy. First-line high-dose chemotherapy might be able to improve the result. This analysis reports toxicity and long-term results of a large phase I/II study of sequential high-dose ...

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