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Antiangiogenetic therapy with pioglitazone, rofecoxib, and metronomic trofosfamide in patients with advanced malignant vascular tumors

Vogt, Thomas ; Hafner, Christian ; Bross, Klaus ; Bataille, Frauke ; Jauch, Karl-Walter ; Berand, Anna ; Landthaler, Michael ; Andreesen, Reinhard ; Reichle, Albrecht



Abstract

BACKGROUND: Systemic therapy options for patients with advanced angiosarcomas are limited, and their prognosis is poor. The idea of angiostatic therapy following the paradigm of metronomic dosed chemotherapeutics combined with proapoptotic biomodulators had not been considered previously in these patients. Therefore, in a pilot study, the efficacy of metronomically scheduled, low-dose ...

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