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Hybrid cell vaccination in metastatic melanoma: clinical and immunologic results of a phase I/II study

Haenssle, Holger A. ; Krause, Stefan W. ; Emmert, Steffen ; Zutt, Markus ; Kretschmer, Lutz ; Schmidberger, Heinz ; Andreesen, Reinhard ; Soruri, Afsaneh



Zusammenfassung

Hybrid cell vaccination with cell fusion products (CFPs) of autologous tumor cells and mature allogenic MHC II bearing dendritic cells has been described to induce cytotoxic T lymphocyte (CTL)-mediated immune responses. The aim of this study was to assess safety, antitumor activity, and immune responses of a CFP-vaccine in patients with disseminated malignant melanoma. In a phase I/II study, we ...

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