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Expression and function of homing-essential molecules and enhanced in vivo homing ability of human peripheral blood-derived hematopoietic progenitor cells after stimulation with stem cell factor

Hart, Christina ; Drewel, Diana ; Mueller, Gunnar ; Grassinger, Jochen ; Zaiss, Matthias ; Kunz-Schughart, Leoni A. ; Andreesen, Reinhard ; Reichle, Albrecht ; Holler, Ernst ; Hennemann, Burkhard



Abstract

Hematopoietic stem cell (HSC) homing from blood to bone marrow is a multistep process involving rolling, extravasation, migration, and finally adhesion in the correct microenvironment. With view to the hematopoietic recovery after clinical stem cell transplantation, we investigated the effect of stem cell factor (SCF) on the expression and the adhesive function of the alpha4beta1 and alpha5beta1 ...

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