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Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation

Holler, Ernst ; Rogler, Gerhard ; Herfarth, Hans ; Brenmoehl, Julia ; Wild, Peter Johannes ; Hahn, Joachim ; Eissner, Günther ; Schölmerich, Jürgen ; Andreesen, Reinhard



Zusammenfassung

Single nucleotide polymorphisms (SNPs) of the NOD2/CARD15 gene resulting in a diminished nuclear factor-kappaB (NF-kappaB) response to bacterial cell wall products have been associated with an increased incidence of Crohn disease. To assess a possible contribution of NOD2/CARD15 mutations to graft-versus-host disease (GvHD) and complications following allogeneic stem cell transplantation, we ...

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