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Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells

Hoffmann, Petra ; Eder, Ruediger ; Kunz-Schughart, Leoni A ; Andreesen, Reinhard ; Edinger, Matthias



Abstract

CD4(+)CD25+ regulatory T (Treg) cells are pivotal for the maintenance of self-tolerance, and their adoptive transfer gives protection from autoimmune diseases and pathogenic alloresponses after solid organ or bone marrow transplantation in murine model systems. In vitro, human CD4(+)CD25+ Treg cells display phenotypic and functional characteristics similar to those of murine CD4(+)CD25+ Treg ...

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