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High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma.

Meidenbauer, Norbert ; Zippelius, Alfred ; Pittet, Mikaël J ; Laumer, Monika ; Vogl, Sandra ; Heymann, Jana ; Rehli, Michael ; Seliger, Barbara ; Schwarz, Stephan ; Le Gal, Frederique-Anne ; Dietrich, Pierre Y ; Andreesen, Reinhard ; Romero, Pedro ; Mackensen, Andreas


Tumor-reactive T cells play an important role in cancer immunosurveillance. Applying the multimer technology, we report here an unexpected high frequency of Melan-A-specific CTLs in a melanoma patient with progressive lymph node metastases, consisting of 18 and 12.8% of total peripheral blood and tumor-infiltrating CD8+ T cells, respectively. Melan-A-specific CTLs revealed a high cytolytic ...


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