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Pioglitazone and rofecoxib combined with angiostatically scheduled trofosfamide in the treatment of far-advanced melanoma and soft tissue sarcoma

Reichle, Albrecht ; Bross, Klaus ; Vogt, Thomas ; Bataille, Frauke ; Wild, Peter ; Berand, Anna ; Krause, Stefan W. ; Andreesen, Reinhard


BACKGROUND: Combined treatment approaches targeting tumor cells as well as stromal cells may control chemorefractory malignancies. In the current study, the authors sought to test one such combined approach in the treatment of chemorefractory melanoma and soft tissue sarcoma. METHODS: A Phase II trial was initiated to analyze the activity of a continuously administered molecularly targeted ...


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