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Expression of heme oxygenase-1 protects endothelial cells from irradiation-induced apoptosis

Ewing, P. ; Wilke, A. ; Eissner, G. ; Holler, E. ; Andreesen, Reinhard ; Gerbitz, A.


A common side effect of therapeutic use of ionizing irradiation is endothelial cell damage resulting in a variety of clinical complications. Thus, preservation of endothelial function after irradiation could potentially limit toxicity. Using the murine endothelioma cell line bEnd2 we show here that induction of heme oxygenase-1 (HO-1) by cobalt protoporphyrine IX (CoPP) inhibits ...


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