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Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8- double-negative regulatory T cells

Fischer, Karin ; Voelkl, Simon ; Heymann, Jana ; Przybylski, Grzegorz K. ; Mondal, Krishna ; Laumer, Monika ; Kunz-Schughart, Leoni ; Schmidt, Christian A. ; Andreesen, Reinhard ; Mackensen, Andreas



Abstract

Down-regulation of immune responses by regulatory T (Treg) cells is an important mechanism involved in the induction of tolerance to allo-antigens (Ags). Recently, a novel subset of Ag-specific T-cell receptor (TCR)alpha beta+ CD4(-)CD8- (double-negative [DN]) Treg cells has been found to be able to prevent the rejection of skin and heart allografts by specifically inhibiting the function of ...

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