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An open-label randomized trial comparing itraconazole oral solution with fluconazole oral solution for primary prophylaxis of fungal infections in patients with haematological malignancy and profound neutropenia

Glasmacher, Axel, Cornely, Oliver, Ullmann, Andrew J., Wedding, Ulrich, Bodenstein, Heinrich, Wandt, Hannes, Boewer, Christian, Pasold, Rita, Wolf, Hans-Heinrich, Hänel, Mathias, Dölken, Gottfried, Junghanss, Christian, Andreesen, Reinhard and Bertz, Hartmut (2006) An open-label randomized trial comparing itraconazole oral solution with fluconazole oral solution for primary prophylaxis of fungal infections in patients with haematological malignancy and profound neutropenia. The Journal of antimicrobial chemotherapy 57 (2), pp. 317-25.

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Abstract

OBJECTIVES: This trial studied the efficacy and safety of itraconazole and fluconazole in the prevention of invasive fungal infections in neutropenic patients with haematological malignancies. PATIENTS AND METHODS: An 8 week, open-label, randomized, parallel-group, multicentre trial comparing itraconazole oral solution (2.5 mg/kg twice daily; N=248) with fluconazole oral solution or capsules (400 ...

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Item type:Article
Date:2006
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
16339606PubMed ID
10.1093/jac/dki440DOI
Classification:
NotationType
AdolescentMESH
AdultMESH
AgedMESH
Antifungal Agents/therapeutic useMESH
Aspergillosis/prevention & controlMESH
Double-Blind MethodMESH
Endpoint DeterminationMESH
FemaleMESH
Fluconazole/therapeutic useMESH
Hematologic Neoplasms/complicationsMESH
HumansMESH
Itraconazole/therapeutic useMESH
Leukocyte CountMESH
MaleMESH
Middle AgedMESH
Mycoses/prevention & controlMESH
Neutropenia/complicationsMESH
NeutrophilsMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:14445
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