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An open-label randomized trial comparing itraconazole oral solution with fluconazole oral solution for primary prophylaxis of fungal infections in patients with haematological malignancy and profound neutropenia

Glasmacher, Axel ; Cornely, Oliver ; Ullmann, Andrew J. ; Wedding, Ulrich ; Bodenstein, Heinrich ; Wandt, Hannes ; Boewer, Christian ; Pasold, Rita ; Wolf, Hans-Heinrich ; Hänel, Mathias ; Dölken, Gottfried ; Junghanss, Christian ; Andreesen, Reinhard ; Bertz, Hartmut


OBJECTIVES: This trial studied the efficacy and safety of itraconazole and fluconazole in the prevention of invasive fungal infections in neutropenic patients with haematological malignancies. PATIENTS AND METHODS: An 8 week, open-label, randomized, parallel-group, multicentre trial comparing itraconazole oral solution (2.5 mg/kg twice daily; N=248) with fluconazole oral solution or capsules (400 ...


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