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Interferon (IFN)-gamma is a main mediator of keratinocyte (HaCaT) apoptosis and contributes to autocrine IFN-gamma and tumour necrosis factor-alpha production

Konur, A. ; Schulz, U. ; Eissner, G. ; Andreesen, Reinhard ; Holler, E.



Abstract

BACKGROUND: Apoptosis of keratinocytes or intestinal epithelial cells is an important pathophysiological mechanism of organ damage during acute graft-versus-host disease. OBJECTIVES: To analyse in detail the mediators and their mutual interaction leading to keratinocyte apoptosis. METHODS: Experiments were performed using a keratinocyte cell line (HaCaT) and human skin explant cultures. RESULTS: ...

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