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Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor

Rehli, Michael ; Sulzbacher, Sabine ; Pape, Sabine ; Ravasi, Timothy ; Wells, Christine A. ; Heinz, Sven ; Söllner, Liane ; El Chartouni, Carol ; Krause, Stefan W. ; Steingrimsson, Eirikur ; Hume, David A. ; Andreesen, Reinhard


Expression of the mouse transcription factor EC (Tfec) is restricted to the myeloid compartment, suggesting a function for Tfec in the development or function of these cells. However, mice lacking Tfec develop normally, indicating a redundant role for Tfec in myeloid cell development. We now report that Tfec is specifically induced in bone marrow-derived macrophages upon stimulation with the Th2 ...


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