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Microsatellite instability: new aspects in the carcinogenesis of colorectal carcinoma

Rüschoff, J. ; Bocker, T. ; Schlegel, J. ; Stumm, G. ; Hofstaedter, Ferdinand


Very recently a new molecular mechanism in the tumorigenesis of colorectal carcinoma has been described which is closely linked to hereditary non-polyposis colonic cancer (HNPCC). Ubiquitous changes in the length of simple repetitive DNA sequences between constitutional and tumour DNA occur in about 90% of cases of HNPCC and in about 15% of cases of non-familial, sporadic colorectal carcinoma. ...


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